An Giang is located in the Mekong Delta, in the southwestern part of Vietnam. The province occupies a position in the upper reaches of the Mekong Delta. The Hau Giang and Tien Giang branches of the Mekong River are the dominant geographical features of the province.
With the exception of the west, most of An Giang is fairly flat and is criss-crossed by many canals and small rivers. This terrain has led to An Giang being a significant agricultural center, producing significant quantities of rice.